منابع مشابه
What controls PTEN and what it controls (in prostate cancer).
T he standard of care for metastatic prostate cancer (PCa) is androgen deprivation therapy since almost all PCa growth is initially reliant on the androgen receptor (AR). However, almost all patients develop resistance to this therapy within 18–24 months, and current treatment for castration-resistant prostate cancer (CRPC) is extremely limited, despite the advent of new drugs that target the A...
متن کاملWhat controls nucleosome positions?
The DNA of eukaryotic genomes is wrapped in nucleosomes, which strongly distort and occlude the DNA from access to most DNA-binding proteins. An understanding of the mechanisms that control nucleosome positioning along the DNA is thus essential to understanding the binding and action of proteins that carry out essential genetic functions. New genome-wide data on in vivo and in vitro nucleosome ...
متن کاملWhat Controls DNA Looping?
The looping of DNA provides a means of communication between sequentially distant genomic sites that operate in tandem to express, copy, and repair the information encoded in the DNA base sequence. The short loops implicated in the expression of bacterial genes suggest that molecular factors other than the naturally stiff double helix are involved in bringing the interacting sites into close sp...
متن کاملCritical Review What Controls TOR?
The target of rapamycin (TOR) is a protein kinase with numerous functions in cell growth control. Some of these functions can be potently inhibited by rapamycin, an immunosuppressive and potential anticancer drug. TOR exists as part of two functionally distinct protein complexes. The functions of TOR complex 1 (TORC1) are effectively inhibited by rapamycin, but the mechanism for this inhibition...
متن کاملCortical dynamics and oscillations : What controls what we see ?
In the previous chapter, I sketched the visual system as a complex network in which lateral and largescale within-area as well as between-areas feedback loops connect brain regions and circuits. The system reaches integral representation through recurrent activation cycles operating at multiple scales within this network. These cycles work in parallel (for instance between ventral and dorsal st...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 1998
ISSN: 0906-6705,1600-0625
DOI: 10.1111/j.1600-0625.1998.tb00315.x